Tetranectin and apolipoprotein A‐I in cerebrospinal fluid as potential biomarkers for Parkinson’s disease
Identifieur interne : 000529 ( Main/Exploration ); précédent : 000528; suivant : 000530Tetranectin and apolipoprotein A‐I in cerebrospinal fluid as potential biomarkers for Parkinson’s disease
Auteurs : E. Wang [République populaire de Chine] ; Y. Sun [République populaire de Chine] ; J. Guo [République populaire de Chine] ; X. Gao [République populaire de Chine] ; J. Hu [République populaire de Chine] ; L. Zhou [République populaire de Chine] ; J. Hu [République populaire de Chine] ; C. Jiang [République populaire de Chine]Source :
- Acta Neurologica Scandinavica [ 0001-6314 ] ; 2010-11.
English descriptors
Abstract
Wang E‐S, Sun Y, Guo J‐G, Gao X, Hu J‐W, Zhou L, Hu J, Jiang C‐C. Tetranectin and apolipoprotein A‐I in cerebrospinal fluid as potential biomarkers for Parkinson’s disease.
Acta Neurol Scand: 2010: 122: 350–359.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard. Objective – The application of biomarkers may potentially improve the efficiency of the diagnosis for Parkinson’s disease (PD). However, no reliable biomarker has been identified to date. This study is aimed to identify proteins that might serve as potential biomarkers for PD diagnosis or pathogenesis. Materials and methods – Two‐dimensional difference gel electrophoresis (2D DIGE) technique, in combination with matrix‐assisted laser desorption/ionization‐time of flight mass spectrometry (MALDI‐TOF MS), was used to determine the differentially expressed cerebrospinal fluid (CSF) proteins in PD patients (n = 3) compared with normal controls (n = 3). Selected proteins were further confirmed by Western blotting analysis in the CSF of PD patients (n = 8), Alzheimer’s disease (AD) patients (n = 6) and normal control subjects (n = 7). Results – Eight proteins were identified after MS and protein database interrogation. In the CSF of PD patients, the expression levels of one isoform of apolipoprotein A‐I (apoA‐I), tetranectin, myosin phosphatase target subunit 1 (MYPT1), and two unknown proteins were down‐regulated, whereas the expression levels of another apoA‐I isoform, proapolipoprotein, and lipoprotein were up‐regulated. Western blotting indicates that the expression of tetranectin was reduced in the CSF from PD patients and elevated in AD, while the expression of apoA‐I was changed only in the CSF from PD patients. Conclusion – Our preliminary results suggest that tetranectin and apoA‐I may serve as potential biomarkers for PD, though further validation is needed.
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DOI: 10.1111/j.1600-0404.2009.01318.x
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Wang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurosurgery, Huashan Hospital, Fudan University; and Shanghai Neurosurgical Center, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurosurgery, Shanghai No. 6 People’s Hospital, Shanghai Jiaotong University; and Shanghai Traumatic Emergency Center, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Y" sort="Sun, Y" uniqKey="Sun Y" first="Y." last="Sun">Y. Sun</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurosurgery, Huashan Hospital, Fudan University; and Shanghai Neurosurgical Center, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurosurgery, Shanghai No. 6 People’s Hospital, Shanghai Jiaotong University; and Shanghai Traumatic Emergency Center, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Guo, J" sort="Guo, J" uniqKey="Guo J" first="J." last="Guo">J. Guo</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Neuroscience, Chinese Academy of Sciences, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Gao, X" sort="Gao, X" uniqKey="Gao X" first="X." last="Gao">X. Gao</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurosurgery, Huashan Hospital, Fudan University; and Shanghai Neurosurgical Center, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Hu, J" sort="Hu, J" uniqKey="Hu J" first="J." last="Hu">J. Hu</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Center for Proteome Analysis, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, L" sort="Zhou, L" uniqKey="Zhou L" first="L." last="Zhou">L. Zhou</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurosurgery, Huashan Hospital, Fudan University; and Shanghai Neurosurgical Center, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Hu, J" sort="Hu, J" uniqKey="Hu J" first="J." last="Hu">J. 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Tetranectin and apolipoprotein A‐I in cerebrospinal fluid as potential biomarkers for Parkinson’s disease.
Acta Neurol Scand: 2010: 122: 350–359.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard. Objective – The application of biomarkers may potentially improve the efficiency of the diagnosis for Parkinson’s disease (PD). However, no reliable biomarker has been identified to date. This study is aimed to identify proteins that might serve as potential biomarkers for PD diagnosis or pathogenesis. Materials and methods – Two‐dimensional difference gel electrophoresis (2D DIGE) technique, in combination with matrix‐assisted laser desorption/ionization‐time of flight mass spectrometry (MALDI‐TOF MS), was used to determine the differentially expressed cerebrospinal fluid (CSF) proteins in PD patients (n = 3) compared with normal controls (n = 3). Selected proteins were further confirmed by Western blotting analysis in the CSF of PD patients (n = 8), Alzheimer’s disease (AD) patients (n = 6) and normal control subjects (n = 7). Results – Eight proteins were identified after MS and protein database interrogation. In the CSF of PD patients, the expression levels of one isoform of apolipoprotein A‐I (apoA‐I), tetranectin, myosin phosphatase target subunit 1 (MYPT1), and two unknown proteins were down‐regulated, whereas the expression levels of another apoA‐I isoform, proapolipoprotein, and lipoprotein were up‐regulated. Western blotting indicates that the expression of tetranectin was reduced in the CSF from PD patients and elevated in AD, while the expression of apoA‐I was changed only in the CSF from PD patients. Conclusion – Our preliminary results suggest that tetranectin and apoA‐I may serve as potential biomarkers for PD, though further validation is needed.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, E" sort="Wang, E" uniqKey="Wang E" first="E." last="Wang">E. Wang</name></noRegion><name sortKey="Gao, X" sort="Gao, X" uniqKey="Gao X" first="X." last="Gao">X. Gao</name><name sortKey="Guo, J" sort="Guo, J" uniqKey="Guo J" first="J." last="Guo">J. Guo</name><name sortKey="Hu, J" sort="Hu, J" uniqKey="Hu J" first="J." last="Hu">J. Hu</name><name sortKey="Hu, J" sort="Hu, J" uniqKey="Hu J" first="J." last="Hu">J. Hu</name><name sortKey="Jiang, C" sort="Jiang, C" uniqKey="Jiang C" first="C." last="Jiang">C. Jiang</name><name sortKey="Sun, Y" sort="Sun, Y" uniqKey="Sun Y" first="Y." last="Sun">Y. Sun</name><name sortKey="Sun, Y" sort="Sun, Y" uniqKey="Sun Y" first="Y." last="Sun">Y. Sun</name><name sortKey="Wang, E" sort="Wang, E" uniqKey="Wang E" first="E." last="Wang">E. Wang</name><name sortKey="Zhou, L" sort="Zhou, L" uniqKey="Zhou L" first="L." last="Zhou">L. Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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